1.遇到(困难),遭到(反对);与...矛盾
1.to have to deal with something difficult or unpleasant
1.When companies trying to find new drugs come up against the nonreproducibility problem, the repercussions can be significant.
当尝试开发新药的公司遇到研究结果无法重复的问题时，可能会产生显著的影响。
2.The question that she continued to come up against, however, concerned internal radiation.
但是，她遇到的问题是关于体内辐射的。
3.The players on show are all illustrious names and talented footballers, so to be able to come up against them is a fantastic opportunity.
场上名单上写的都是著名的名字和极具天赋的球员。所以能够对阵他们是个了不起的机会。
4.By this time the German tanks had come up against the excellent Soviet T-34, and armour and armament were being increased.
那时候，德军坦克已经可以对抗苏联优秀的T-34中型坦克，且装甲和火力正持续提升。
5.The issue of Python is another one of those make-or-break questions you'll come up against in deciding on your cloud computing platform.
在选择云计算平台时，Python的问题是您将遇到的另一个决定成败的问题。
6.You might come up against a bit of opposition.
你可能会遭到一点反对。
7.You may come up against a bit of opposition.
你可能会遭到一些反对。
8.Ferrara will come up against a familiar face in the form of Laurent Blanc, the Bordeaux boss who was a former colleague at Napoli.
费拉拉将会在这场比赛中遇到老熟人，因为波尔多主教练劳伦特。布兰科在球员时代曾效力过那不勒斯。
9.Come up against her to biting a cake, she says hastily: "Dear, I am eating the breakfast tomorrow, should you eat together? "
碰到她正在咬着一块蛋糕，她慌张地说：“亲爱的，我在吃明天的早餐，你要不要一起吃？”英文夫妻笑话：Themadamisreducingweight。
10.But even if there had been no banking crisis they would sooner or later have come up against prudential limits to their debt ratios.
但即使没有银行业危机，他们也迟早会遇到债务比例的审慎限制。